Efficacy Of H2 Receptor Antagonist In Prevention Of Thienopyridine
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|First Posted : April 16, 2015Results First Posted : March 11, 2019Last Update Posted : March 11, 2019|
- Study Details
|Drug: histamine-2 receptor antagonistDrug: Placebo||Not Applicable|
Taking Your H2 Blockers
H2 blockers are most often taken by mouth. You can get them in the form of tablets, liquids, or capsules.
- These medicines are most often taken with the first meal of the day. In some cases, you may also take them before your evening meal.
- It takes 30 to 90 minutes for the medicines to work. The benefits will last several hours. People often take the drugs at bedtime, as well.
- Symptoms may improve for up to 24 hours after taking the drug.
H2 blockers may be bought in lower doses at the store without a prescription. If you find yourself taking these most days for 2 weeks or more for acid reflux symptoms, make sure you see your health care provider about your symptoms.
If you have a peptic ulcer, your provider may prescribe H2 blockers along with 2 or 3 other medicines for up to 2 weeks.
If your provider prescribed these medicines for you:
- Take all of your medicines as your provider told you to. Try to take them at the same time each day.
- Do not stop taking your medicines without talking to your provider first. Follow up with your provider regularly.
- Plan ahead so that you do not run out of medicine. Make sure you have enough with you when you travel.
What Are The Risks Of H2 Blockers
While some may experience mild to moderate symptoms associated with H2 blockers, there may be safety issues relating to long-term treatment. High doses of cimetidine may cause reversible impotence or gynecomastia and may interact with many other medical drug prescriptions. Long-term use of H2 blockers for acid suppression may include the risk of proliferation of gastric flora and hyperplasia which may result in gastric malignancy.
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What Over The Counter Medicine Is Best For Stomach Pain
Video answer: How to choose the right over-the-counter pain medication for you
9 other answers
Best OTC Products for Digestive Problems. Prilosec OTC, TUMS, Emetrol and MiraLAX are recommended by many pharmacists for a range of digestive issues. By Ruben Castaneda.
There are two main types of OTC medications used to treat nausea and vomiting: Bismuth subsalicylate, the active ingredient in OTC medications like Kaopectate® and Pepto-Bismol, protects your stomach lining. Bismuth subsalicylate is also used to treat ulcers, upset stomach and diarrhea.
Considered by most users as the best medicine for bloating, Imodium Multi-Symptom Relief Caplets target not just flatulence, but also all other symptoms of stomach disturbance. This includes cramps, pressure, and diarrhea. Imodium is one of the most popular brands for gastrointestinal relief, which is why it has developed a wide base of consumers.
Best for Stomach Aches: Pepto Bismol LiquiCaps at Amazon Effective in remedying excessive gas experienced in conjunction with an upset stomach. Best Gummy: Alka-Seltzer Heartburn + Gas Relief Chews at Amazon For folks who struggle with swallowing pills, a tasty gummy that helps relieve excessive gas, heartburn, acid indigestion, and more.
Over-the-Counter Medications For gas pain, medicine that has the ingredient simethicone can help get rid of it. For heartburn from gastroesophageal reflux disease , try an
For Nausea and Vomiting
Drug Interactions Of Famotidine Vs Omeprazole
Famotidine primarily interacts with drugs that depend on stomach acid for absorption. These drugs include antiretrovirals, such as atazanavir and rilpivirine, and antifungals, such as ketoconazole and itraconazole. Taking famotidine can decrease the absorption of these drugs and decrease their overall effectiveness.
Famotidine can also interact with tizanidine, a muscle relaxer that is processed by the CYP1A2 enzyme in the liver. Famotidine can increase levels of tizanidine in the body which can lead to low blood pressure , slow heartbeat , or extreme drowsiness.
Omeprazole also interacts with some antiretroviral medications, which can lead to a decrease in their effectiveness. Unlike famotidine, omeprazole can interact with drugs that are processed by the CYP2C19 and CYP3A4 enzymes in the liver. These drugs may include tacrolimus and rifampin, among other drugs.
Omeprazole can interact with warfarin and increase the risk of abnormal bleeding. Taking omeprazole with an immunosuppressant called methotrexate can lead to methotrexate toxicity.
This may not be a complete list of all possible drug interactions. Consult a doctor with all the medications you may be taking.
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Switching From Ppi To H2 Blocker:
Switching from one drug to another requires proper supervision of a doctor or a nurse. If not properly supervised it can harm patients health.
Cimetidine and famotidine are the most prescribed h2 blockers. These are second in line treatment medications for acid reflux. If PPIs such as omeprazole fail to cure acid reflux, then the doctor will advise you to shift to taking h2 blockers.
Sometimes in severe cases of GERD, doctors prescribe a combination of both h2 blockers and PPI, but this is rare.
Before taking H2 blockers make sure you have taken advice from the doctor. Do not change medication yourself or it can result in serious side effects. Even a sudden shift of medication can case backlash side effects, which could be fatal for the patient.
Coverage And Cost Comparison Of Famotidine Vs Omeprazole
Most Medicare Part D plans and other insurance plans will cover generic famotidine tablets. Famotidine can cost a retail price of $100 on average if you dont have insurance coverage. If youre looking for the best deal, SingleCare offers discount coupons on drugs like famotidine. With a SingleCare famotidine coupon, you can expect to pay $9-$30.
Omeprazole delayed-release capsules are covered by most Medicare and insurance plans. The average retail cost of omeprazole is about $70 on average. For generic omeprazole capsules, you can use a SingleCare coupon card to lower this cost. With a SingleCare omeprazole coupon, you can reduce the price to around $15 for 30 20 mg capsules.
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Stomach Cancer And Other Conditions Associated With H Pylori
H pylori is strongly associated with certain cancers. Some studies have also linked it to a number of non-gastrointestinal illnesses, although the evidence is inconsistent.
Stomach cancer, also called gastric cancer, is the third leading cause of cancer death worldwide. In developing countries, where the rate of H pylori is very high, the risk of stomach cancer is six times higher than in the United States. Evidence now suggests that H pylori may be as carcinogenic to the stomach as cigarette smoke is to the lungs.
Infection with H pylori promotes a precancerous condition called atrophic gastritis. The process most likely starts in childhood. It may lead to cancer through the following steps:
- The stomach becomes chronically inflamed and loses patches of glands that secrete protein and acid.
- New cells replace destroyed cells. But the new cells do not produce enough acid to protect against carcinogens.
- Over time, cancer cells may develop and multiply in the stomach.
Although the evidence is mixed, some research suggests that early elimination of H pylori may reduce the risk of stomach cancer to that of the general population. It is important to follow patients after treatment for a long period of time.
H pylori also is weakly associated with other non-intestinal disorders, including migraine headache, Raynaud disease , and skin disorders such as chronic hives.
How Are Peptic Ulcers Diagnosed
If your doctor suspects you might have a peptic ulcer, he will take a full medical history and perform a physical exam. Diagnostic tests you might take include:
- Lab test for H. pylori A blood, stool, or breath test may be used to determine whether H. pylori bacteria are present in your body.
- Endoscopy During this procedure, a hollow tube with a lens will be passed down your throat to your esophagus, stomach, and small intestine. This will allow your doctor to look for a peptic ulcer and take a biopsy if one is present.
- Barium swallow For this test, you will swallow a white liquid containing barium, which coats your digestive tract. A series of X-rays of your upper digestive system will be taken and the liquid makes the ulcer more visible.
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Interference With Drug Absorption
H2-receptor antagonists may interfere with the absorption of other drugs or themselves by altering gastric emptying, binding directly to another drug, or altering intragastric pH. Cimetidine has been reported to delay gastric emptying, whereas ranitidine and nizatidine accelerate it. Antacids and sucralfate bind to and inhibit the absorption of H2-receptor antagonists by 1025%. Certain drugs that are weak bases, such as the antifungal medications ketoconazole and itraconazole, require an acid environment for optimal absorption. As the pH rises in response to H2-receptor antagonists, the absorption of these drugs decreases.
In , 2016
New Information May Affect Your Approach To Treatment
Millions of people turn to prescription and over-the-counter medications to cope with heartburn from gastroesophageal reflux disease or other stomach conditions. But navigating the risks of heartburn remedies can leave a sour taste in your mouth, since some have been tied to health concerns. Here’s what you need to know about two mainstays of treatment, and how the latest developments may affect you.
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What Is The Safest Acid Reflux Medicine
Everyone responds to medications differently. Therefore, the safest acid reflux medicine is the one that works best for you with the least amount of side effects. When compared to famotidine, omeprazole may have an increased risk of adverse effects, such as osteoporosis, especially when used long term.
Peptic Ulcer Disease Treatment
Peptic ulcers are often caused by an overproduction of gastric acid. Many treatment options focus on reducing or suppressing gastric acid production. If your doctor determines that you have an H. pylori infection, you will need treatment for that as well.
The goal of treatment for peptic ulcer disease is to:
- Relieve symptoms
Treatments for peptic ulcer disease include:
Sometimes, treatment leads to complications.
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How Do H2 Receptor Blockers Work
When you take an H2 receptor blocker, the active ingredients travel to specific receptors on the surface of the stomach cells that release acids. The medication inhibits certain chemical reactions in these cells so that they arent able to produce as much acid. According to the National Institutes of Health, H2 receptor blockers decrease stomach acid secretions over a 24-hour period by 70 percent. By reducing the amount of acid in the stomach, any damaged tissues are allowed time to heal.
Most of the side effects associated with H2 receptor blockers are mild and usually subside as a person takes the medication over time. Only 1.5 percent of people stop taking H2 receptor blockers due to the side effects.
Some of the side effects that may occur with H2 receptor blockers include:
- suicidal thoughts
Despite their potential side effects, H2 receptor blockers are usually a very effective treatment for conditions that cause excess stomach acid. You and your doctor can discuss the potential risks and determine whether H2 receptor blockers are the best option for your particular condition. You should never stop taking your medication without talking to your doctor about it first.
How Well Or Quickly Do H2 Blockers Work
No one H2 blocker is thought to work any better than another. However, the newer group of medicines mentioned above – proton pump inhibitors – also reduce the amount of acid produced by the stomach. They include omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole. In general, proton pump inhibitors are used first because they are better than H2 blockers at reducing stomach acid. However, if you don’t get on with a proton pump inhibitor , your doctor may prescribe an H2 blocker.
Generally, H2 blockers are well absorbed by the body and can provide quick relief of symptoms from some problems. For example, heartburn caused by reflux. However, if you are taking them for other reasons, such as to heal an ulcer, it may take longer for the medication to have an underlying effect.
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If Your Ulcer Was Caused By Helicobacter Pylori
Most stomach ulcers are caused by infection with H. pylori. Therefore, a main part of the treatment is to clear this infection. If this infection is not cleared, the ulcer is likely to return once you stop taking acid-suppressing medication. For more information, see the separate leaflet called Helicobacter Pylori.
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What If A Peptic Ulcer Doesnt Heal
Most often, medicines heal a peptic ulcer. If an H. pylori infection caused your peptic ulcer, you should finish all of your antibiotics and take any other medicines your doctor prescribes. The infection and peptic ulcer will heal only if you take all medicines as your doctor prescribes.
When you have finished your medicines, your doctor may do another breath or stool test in 4 weeks or more to be sure the H. pylori infection is gone. Sometimes, H. pylori bacteria are still present, even after you have taken all the medicines correctly. If the infection is still present, your peptic ulcer could return or, rarely, stomach cancer could develop. Your doctor will prescribe different antibiotics to get rid of the infection and cure your peptic ulcer.
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Drug Treatment Of Stomach Acid
, MD, University of Wisconsin School of Medicine and Public Health
, and gastroesophageal reflux disease Gastroesophageal Reflux Disease In gastroesophageal reflux disease, stomach contents, including acid and bile, flow backward from the stomach into the esophagus, causing inflammation in the esophagus and pain in the bottom… read more . Although the amount of acid present in the stomach is usually normal in people with these disorders, reducing the amount of acid in the stomach is important in treating the damage to the stomach and intestines as well as in relieving symptoms.
Can I Use Famotidine Or Omeprazole With Alcohol
Famotidine should be avoided with alcohol. Drinking alcohol while taking famotidine can increase the risk of CNS effects like confusion or drowsiness. Omeprazole may be fine to take with alcohol in moderation. However, mixing medications with alcohol should be avoided when possible, especially if you notice an increase in side effects.
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Is Famotidine Or Omeprazole More Effective
Both famotidine and omeprazole can be effective drugs for treating GERD and other digestive conditions. However, the general consensus is that omeprazole is a more potent drug than famotidine.
Randomized, clinical trials have shown that PPIs are more effective in treating duodenal ulcers than H2 blockers. PPIs were found to significantly increase ulcer healing compared to H2 blockers. No significant differences were found between the PPIs that were studied, which included Prevacid , Protonix , and Aciphex .
In people who take blood thinners, such as clopidogrel and aspirin, a PPI or H2 blocker can be used to prevent ulcers. One systematic review found that PPIs were superior to H2 blockers in preventing gastric ulcers. The studies in the review mostly compared Prilosec or Nexium with Pepcid or Zantac .
Its important to seek medical advice from your healthcare provider before taking famotidine or omeprazole. The more effective drug is ultimately the one that works best for your condition.
What Else Can I Do
If certain foods bother you, do not eat them. You may heal faster if you do not smoke or use aspirin or ibuprofen. Acetaminophen will not hurt your stomach.
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The Best Otc Drugs For Ulcers
According to the University of Maryland Medical Center, 10 out of every 100 Americans will suffer an ulcer in their lifetime 3. Many over-the-counter medications are available to relieve your pain and assist the healing process. Each medication has a separate function, though the drugs serve the same purpose: pain relief and acid digestion. You can choose from acid neutralizers, acid blockers and drugs that stop acid production altogether.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
What Are The Benefits Of H2 Blockers
H2 blockers are easily available over-the-counter at most pharmacies, making them an easy solution for heartburn relief, indigestion, or acid indigestion. H2 blocker medications are most often taken orally with the first meal of the day. It may take only 30-90 minutes for the H2 blocker to start working, and the benefits may up to 24 hours after dosage. Healthcare providers may prescribe H2 blockers alongside other medications during treatment for peptic ulcers.
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