Thursday, June 16, 2022

What Is An Infusion For Ulcerative Colitis

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Does Ulcerative Colitis Make You Immunocompromised

Infliximab for Patients with Severe Ulcerative Colitis – IBD in the News

Ulcerative colitis doesnt make you immunocompromised. Some of the medicines that treat it may change the way your immune system responds. This change is different for each medication. Some of these changes may increase the risk of certain infections or other issues. A discussion with your health care team before starting a medication is the best way to understand these risks and ways to prevent them.

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The Pros And Cons Of Biologics For Ulcerative Colitis

The introduction of biologics has changed treatment for many people with ulcerative colitis. Heres what you need to know about the risks and benefits.

Over the past 15 years, treatment options for ulcerative colitis have expanded quite a bit. Among the newer options is a class of drugs called biologics.

Biologics are derived from natural sources, such as human or animal genes or microorganisms, and are designed to act on the immune system, specifically the parts that play key roles in fueling inflammation.

As inflammation is thought to be a cornerstone of the process involved in the manifestation of inflammatory bowel diseases, like Crohns disease and ulcerative colitis, they have proved to be very effective as treatment for certain patients, says Donald Tsynman, MD, a gastroenterologist at NewYork-Presbyterian Hospital in New York City.

The fact that biologics target the activity of the patients own immune system is what sets them apart from some other medications for ulcerative colitis, Dr. Tsynman says.

What Does Having An Infusion Feel Like

Everyone is unique, experiencing pain and discomfort differently, so this is a hard question to answer. People report varying levels of discomfort at having a cannula inserted into their vein, some experiencing little or no discomfort at all. Most people dont feel anything when the medicine goes into their vein, although occasionally it can feel cool for a short time.

The build up to, and worry about having, an infusion can often be worse than the actual infusion itself. On top of that you might be concerned about the time it takes to have an infusion, the need to take time off work, or organise childcare. You may find it becomes easier after a few treatments, are more familiar with the routine, and know what to expect. Hopefully by then you will also be feeling better.

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What Are The Outcomes Of Remicade Infusion

Remicade works differently than other medications by targeting a specific protein in the bodys immune system which helps control inflammation. Remicade can reduce signs and symptoms, induce and maintain remission, promote intestinal healing and reduce or stop the need for steroids. People who take Remicade for their IBD symptoms usually experience a period of remission, an inactive time in the disease process.

Whats It Like To Receive An Infusion Of A Biologic

Infliximab infusion for Crohn

Today I will be focusing on what its like to receive an infusion of a biologic medication. When I first started dating my boyfriend I was receiving one biologic via infusion in Michigan and he was on another biologic and receiving it in Illinois where he lives. Ive had my infusions done at 3 different locations and have gone with him for his to a couple locations.

What is interesting about infusions is that it seems like regardless of the medication being received or the location there is a lot about the process that remains the same or very similar. With that said keep in mind that this is just a general post and experiences will vary slightly.

Currently Remicade, Entyvio, and Tysabri are the biologics that are approved to treat Crohnâs disease and ulcerative colitis in the US and can be administered by infusion. One drug on the horizon for the treatment of IBD will begin with an induction of an infusion and will then switch to self-injection after the initial infusion dose.

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Can I Treat Ibd If I Am Pregnant Or Breastfeeding

Yes, but your doctor may change the type or amount of the medicine you take. Some medicines, such as methotrexate and thalidomide, cause birth defects and other health problems and should not be taken while you are pregnant or breastfeeding.31

Before you get pregnant, make a plan with your obstetrician and gastroenterologist about the medicines you will take during and after pregnancy. Take your medicines as your doctor tells you to. If you stop taking your medicines and your symptoms come back , it may be difficult to get them back under control.31

Talk with your doctor about your medicines and breastfeeding before you give birth. You can search for your medicine in the LactMed database to find out if your medicine passes through your breastmilk and, if so, if it has any possible side effects for your nursing baby.

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Complications Of Ulcerative Colitis

Ulcerative Colitis is a chronic inflammatory disease of the colon. The inflammation may be limited to one area of the colon or it may be spread out in patches through the entire length of the large intestine.Ulcerative Colitis is not contagious, but it does include side effects such as rectal bleeding, abdominal pain, fatigue and weight loss.

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Important Safety Informationabout Entyvio

  • The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
  • Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back have liver problems have tuberculosis or have been in close contact with someone with TB have recently received or are scheduled to receive a vaccine or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.
  • Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call .

    Things To Know About Biologics For Ulcerative Colitis

    Ulcerative colitis / remicade infusion day

    Biologics are one option in the treatment of ulcerative colitis. Heres what you should know before starting biologic therapy.

    If you have moderate to severe ulcerative colitis and arenât responding to or canât tolerate traditional medications, such as aminosalicylates or immunomodulators, your doctor may ask you to start taking a biologic.

    Biologic drugs, such as adalimumab and infliximab, can help stop inflammation and keep your disease in remission if other UC medications arent effective. But these drugs are also complex and may not work for everyone, so its important to learn more about them if youre new to biologic therapy.

    Here are 10 key facts about biologic drugs for UC.

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    Being On An Immunosuppressant Medicine For Your Crohns Or Colitis Does Not Mean That You Dont Have An Immune Systembeing On Certain Immunosuppressant Medicines May Make The Vaccine Less Effective Your Immune System Is Still Able To Fight Off Infections Just Not Quite As Well As Other People Therefore You Are Still Able To Have Vaccines That Are Not Live Vaccines No Matter What Medicine You Take For Your Crohns Or Colitis None Of The Covid

    If you were taking immunosuppressants around the time of your first two vaccines you may be eligible for a third dose.

    Crohnâs & Colitis UK are supporting the research study CLARITY, which is looking at antibodies in people on infliximab and vedolizumab. The study found that people on infliximab produced fewer antibodies after one vaccine, but most people produced a good number of antibodies after the second vaccine. Read the full results on CLARITY.

    This does not mean you should stop your treatment. Stopping treatment can lead to a flare of your Crohnâs or Colitis, which puts you at greater risk from serious complications of COVID-19. Even if the COVID-19 vaccine works slightly less well for you, it will still offer greater protection than not having the vaccine.

    I would recommend everyone with Crohnâs or Colitis to have the coronavirus vaccine as I recently had mine. I feel it is important especially for those who are immunosuppressed we are all here to fight it together with the support and guidance from Crohnâs & Colitis UK, who can provide you with more advice and information.

    Daljit ChohanIBD Specialist Nurse

    Learning to manage ulcerative colitis is important for your overall comfort and health. At Amber Specialty Pharmacy, one of the ways we help patients manage their UC is by providing resources for nutrition and tips for infusion therapy.

    Ulcerative Colitis and Nutrition

    Nutrition Tips for People with Ulcerative Colitis

    Symptoms Of Rheumatoid Arthritis:

    Rheumatoid Arthritis is a chronic disease characterized by periods of disease flares and remissions. Early rheumatoid arthritis tends to affect your smaller joints first particularly the joints that attach your fingers to your hands and your toes to your feet. Rheumatoid arthritis symptoms vary in severity and include:

    • Joint pain, such as in the joints of the feet, hands, and knees
    • Swollen joints

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    Is Remicade A Form Of Chemotherapy

    No, Remicade isnt a form of chemotherapy. Remicade is a biologic, which means its made from living organisms. Specifically, Remicade is monoclonal antibody thats made from immune system cells in a lab. Monoclonal antibodies only block the activity of certain proteins in the body.

    Chemotherapy, on the other hand, is a chemical drug that destroys rapidly growing cells throughout the body. Its typically used to treat cancer. Chemotherapy medications affect many types of cells and organs. This is different from the very specific actions of monoclonal antibodies, such as Remicade.

    Tips For Infusion Day

    Infusion Therapy Treatment for Ulcerative Colitis

    Its been two years since I started getting my medication for my ulcerative colitis by infusion. I get my infusions every six weeks, which isnt quite often enough to completely get used to them. I still wake up early each infusion morning remembering I have an appointment and worrying Ill sleep through my alarm and miss it. But in the two years Ive been doing this, I have learned a few things along the way.

    1. Bring things to do that you enjoy. Some infusions have lasted three hours, plus the time spent in the waiting room and waiting for the medication to arrive. Compared with that experience, the half-hour infusion usually flies by. But as with any doctors appointment, I never know how long Ill have to spend waiting around, and I like having multiple options to distract me. I usually bring something fun to read or download a couple of episodes of a show I like onto my iPad, and I make sure I have music or podcasts to listen to. Sometimes I even bring a coloring book. I rarely ever use all of these options, but it makes me feel better knowing I have them.

    3. Drink lots of water beforehand. I cant believe it took me two years to figure this one out. Before every infusion, a nurse would spend what felt like an eternity poking around at my arm trying to find a good vein. Sometimes it would take more than one person to try putting in an IV. Since I started making a conscious effort to drink more water before my appointment, I havent had that problem.

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    How Do Doctors Treat Symptoms And Complications Of Ulcerative Colitis

    Doctors may recommend or prescribe other treatments for symptoms or complications of ulcerative colitis. Talk with your doctor before taking any over-the-counter medicines.

    To treat mild pain, doctors may recommend acetaminophen instead of nonsteroidal anti-inflammatory drugs . People with ulcerative colitis should avoid taking NSAIDs for pain because these medicines can make symptoms worse.

    To prevent or slow loss of bone mass and osteoporosis, doctors may recommend calcium and vitamin D supplements or medicines, if needed. For safety reasons, talk with your doctor before using dietary supplements or any other complementary or alternative medicines or practices.

    Doctors most often treat severe complications in a hospital. Doctors may give

    • antibiotics, if severe ulcerative colitis or complications lead to infection

    How Do Doctors Treat Ulcerative Colitis

    Doctors treat ulcerative colitis with medicines and surgery. Each person experiences ulcerative colitis differently, and doctors recommend treatments based on how severe ulcerative colitis is and how much of the large intestine is affected. Doctors most often treat severe and fulminant ulcerative colitis in a hospital.

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    Inflammatory Bowel Disease Treatment Options

    IBD is a lifelong disease, and at this point, people are rarely cured. However, thanks to advances in medication, gastroenterologists at CHI Health can help patients keep their condition in check and live an active, pain-free lifestyle.

    The most common medications we prescribe include:

    • Aminosalicylates: These treat mild to moderate Crohns disease by controlling inflammation in the lining of the gastrointestinal tract.
    • Antibiotics: These treat symptoms and help heal infections.
    • Biologics: These drugs treat people with moderate to severe disease, often if other drugs have not worked well. They dont affect your whole immune system, so they tend to cause fewer side effects, although some side effects can be serious.
    • Corticosteroids: These strong and fast-acting drugs can often relieve flares in moderate to severe Crohns within a few days. You usually take them in small doses for a short time because they can cause serious side effects.
    • Immunomodulators: If you have moderate to severe Crohns, and you have not had luck with aminosalicylates or corticosteroids, your doctor may suggest one of these. They can help your body respond better to corticosteroids during a flare and help you stay flare-free longer.

    Back Pain And Ulcerative Colitis

    What is A Remicade Infusion Like?

    Research indicates that nearly 25 percent of people with inflammatory bowel disease including ulcerative colitis and Crohns disease experience chronic lower back pain. Ankylosing spondylitis and axial arthritis both of which can cause back pain are two common causes of back pain in people with UC.

    That said, a doctor may not suspect that a person with back pain has UC unless they also experience gastrointestinal symptoms. If you do experience back pain, its important to let your doctor know even if you dont suspect that its related to UC. They will be able to determine the cause of your pain and work with you to find the best way of managing it.

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    Will I Need To Use This Drug Long Term

    Remicade is meant to be used as a long-term treatment. If you and your doctor determine that Remicade is safe and effective for you, youll likely take it long term.

    You may wonder how Remicade compares with other medications that are prescribed for similar uses. Here we look at how Remicade and Humira are alike and different.

    Tips To Make The Infusion Experience Better

    • If you are getting Remicade ask your doctor about Rapid Remicade. There have been studies done that found that the standard 2 hour infusion can be done in half the time safely and successfully. I got rapid Remicade when I was on it and it shortened the infusion time by half!
    • Bring things with you to occupy your time. I liked to bring my computer and headphones with me to keep me entertained. Many of the times I would work on blog posts for my website. Other ideas are: A book to read, coloring books, homework, your planner to organize your week, etc.
    • Dress comfortable. When I was first on Remicade I used to wear my pajamas and sleep during my infusion because the IV Benedryl I was given as a pre-med would make me sleepy. I got used to it over time and could no longer sleep during infusions but I still liked to dress comfy unless I had somewhere to be afterward.

    Hope this helps you understand what infusions are like. If you are currently receiving infusions of biologic medications what has been your experience? Is it similar or different? Let us know in the comments!

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    The Advantages Of Biologics For Ulcerative Colitis

    Biologics can improve gut symptoms, bringing about and maintaining remission in people with moderate to severe ulcerative colitis. They can also reduce the need for hospitalization and surgery, says the British organization Crohn’s & Colitis UK.

    One key advantage of biologic therapies over other types of treatment for ulcerative colitis is that their mechanisms of action are more precisely targeted to the factors responsible for the condition, notes the Crohns & Colitis Foundation.

    Unlike corticosteroids, for example, which affect the whole body and may produce major side effects, biologic agents act more selectively. These therapies are targeted to particular proteins that have already been proven to be involved in ulcerative colitis.

    Patients are often nervous about biologics, says Laura Raffals, MD, a gastroenterologist at the Mayo Clinic in Rochester, Minnesota. But theyre not as scared about taking a corticosteroid, and thats an important conversation to have because the data shows that patients on biologics are much safer and stay in remission longer. The serious side effects we see are from steroids or narcotics, not biologics.

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