Thursday, August 11, 2022

Ulcerative Colitis And Hair Loss

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UC can be a painful and uncomfortable inflammatory condition that affects both the large intestine and the rectum.

When a person has UC, small ulcers develop in the lining of their colon. These can produce pus and bleed.

The main symptoms of UC are:

  • ongoing problems with diarrhea
  • blood, mucus, or pus in stools
  • the need to pass stool often
  • weight loss

What Is Crohns Disease

Crohns disease is a chronic condition that can flare up for periods of time, then go into remission. Along with ulcerative colitis, it is a type of IBD. The whole bowel wall can become inflamed, or the condition may occur in patches, with healthy parts of the bowel mixed among inflamed parts.

2015 study suggests that using mesalamine may provide some protection from hair loss.

The study found that, out of 150 people with IBD, around one-third reported hair loss. People who took mesalamine or anti-tumor necrosis factor medications reported the least hair loss. The researchers suggested that the drugs may have prevented hair loss, although they were unsure how.

According to a 2021 study, treatment with thiopurines may also result in hair loss. Researchers note that a persons hair should grow back once treatment has finished.

Ulcerative Colitis And Weight Loss

Appetite loss is a challenge for people with UC. Symptoms like pain, nausea, bloating, and diarrhea may make you less likely to want to eat. Fatigue can deter you from preparing food.

You could feel full quickly and stop eating before youâve taken in enough calories. And maybe youâre anxious about trying new foods for fear theyâll worsen your symptoms.

Some researchers believe the inflammation of UC itself causes weight loss. Inflammation in your intestines is thought to increase a digestive hormone that tells your body youâre full. This could be your bodyâs way of protecting itself from foods that inflame your gut.

But inflammation means you need more, not fewer, calories to help you heal. Try your best to eat during a flare, even if you donât feel up to it.

To deal with appetite loss:

  • Eat smaller portions throughout the day, which keeps your blood sugar levels steady and discourages bloating
  • Choose nutritious foods that you like
  • Adjust your foodâs temperature if hot or cold meals trigger nausea
  • Drink plenty of fluids

If you struggle with your appetite, tell your doctor. Proper treatment of inflammation could help ease this symptom.

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Entyvio And Hair Loss

My daughter had a Crohns flare this past year which culminated in surgery in August. During this time she has lost approximately 40 pounds. She came through the surgery fine but had no appetite and found it difficult to eat after the surgery. She is finding out what food she can tolerate now. She has been on Entyvio infusions and her last one was in September. Her hair is falling out by the handful. She is taking several medications, but we are thinking it is the Entyvio. Has anyone with Crohns suffered a severe hair loss? Has anyone had this happen due to Entyvio? Has the hair loss been permanent or does it grow back after a while?

Hi that must be so frustrating to have your daughter experience hair loss along with the Crohns symptoms.Here is an article from Medical News Today on entyvio. Note that it says others have reported hair loss with entvio but their has been no evidence of this in the medications studies.

has experience with entyvio and may be able to share their experience.

Back to you have you asked your daughters doctor about this?

Hi that must be so frustrating to have your daughter experience hair loss along with the Crohns symptoms.Here is an article from Medical News Today on entyvio. Note that it says others have reported hair loss with entvio but their has been no evidence of this in the medications studies.

What Can You Expect From Immunosuppressants

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Your doctor may suggest an immunosuppressant treatment if:

  • You arenât responding to other treatments such as aminosalicylates, antibiotics, or corticosteroids, or you have severe side effects.
  • Your body has become dependent on steroids and you need to come off them.
  • You have perianal disease or a fistula .
  • Youâre taking a biologic and need to help it work better and keep your body from trying to fight it.

Doctors mainly prescribe immunosuppressants when other treatments havenât kept your inflammation under control. Theyâre useful as maintenance therapy, meaning youâve already reached remission and want to stay there.

They can also help make biologic drugs more effective. When you take a biologic, your body may want to fight against it. By slowing down your immune system, immunosuppressants make your body less likely to do that.

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Be Gentle With Your Hair

In the meantime, treating hair gently is important, Gagneja says.

That means cutting down or eliminating hair coloring and perms, avoiding hairstyles that involve pulling on the hair â such as tying it in a tight ponytail or bun â and minimizing excessive brushing.

Gagneja also suggests using a gentle shampoo and potentially washing your hair less often. There are hair masks that promise to add nutrients to hair, but be careful not to overdo these treatments.

Should Treatment For Crohn’s Stop Because Of Hair Loss

I know Im not alone in experiencing a significant hair loss due to their Crohns. And I know, from experience, that there are many who are experiencing the same if not worse, right now.

I also know for a fact that some will blame their Crohns or ulcerative colitis treatment and want to abandon the treatment because of vanity.

Im writing this in hopes that if you too are experiencing the same that you will know that you are not alone. It will grow back.

Ive seen far too many people comment on social media that their hair is falling out or theyve gained weight since starting treatment and want to quit. Please do not stop your treatment because of hair loss or weight gain.

While I do realize that my hair has vastly changed since starting this new treatment, I am the healthiest Crohns-wise that Ive been in 3 decades. Thats huge!

Its because of Crohns that Im on certain treatments. It’s because of Crohn’s that I do not absorb nutrition properly. So, I try not to view the problem as coming only from my meds. It took a while to arrive here, but now I blame Crohns for stealing my hair.

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The Main Types Of Drugs

The aim of drug treatment for Ulcerative Colitis is to reduce inflammation. The main types of drugs are:

Aminosalicylates reduce inflammation in the lining of the intestine. Examples include mesalazine , olsalazine , sulphasalazine and balsalazide .

Corticosteroids work by blocking the substances that trigger allergic and inflammatory responses in your body. They include prednisolone, prednisone, methylprednisolone, budesonide , hydrocortisone and beclometasone dipropionate .

Immunosuppressants suppress the immune system, and reduce levels of inflammation. The main immunosuppressants used in IBD are azathioprine , mercaptopurine or 6MP , methotrexate, ciclosporin and tacrolimus. They are often used in patients who relapse when they come off steroids.

Biological drugs are the newest group of drugs used to treat IBD. Anti-TNF drugs, such as infliximab , adalimumab and golimumab target a protein in the body called TNF, or tumor necrosis factor, preventing inflammation. Another type of biological drug is vedolizumab , which works by stopping white blood cells from entering the lining of the gut and causing inflammation.

You can find more information about some of the drugs used for Colitis: Adalimumab, Aminosalicylates , Azathioprine and Mercaptopurine, Biologic Drugs, Golimumab, Methotrexate, Infliximab, Steroids, Ustekinumab and Vedolizumab.

About a quarter of people diagnosed with Crohns or Colitis are children or adolescents at the time they are diagnosed.

Can Elimination Diets Cure It

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Up to 60% of IBD patients have tried an elimination diet to relieve ulcerative colitis symptoms .

Unfortunately, the only known cure is total surgical removal of the colon and rectum .

There is no scientific proof that any diet can cause remission on its own. However, limited evidence suggests that certain diets can greatly improve comfort and quality of life.

The impact of diet on inflammatory bowel disease. Click to enlarge. Image .

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Clinical Trials & The Reported Side Effects Of Xeljanz

The studys co-author, Dr. Craiglow, said, By eight months there was full regrowth of hair. The patient has reported feeling no side effects, and weve seen no lab test abnormalities, either.

The results from this study are extremely encouraging, however, further, wider-scale clinical trials are required in order to establish whether the use of tofacitinib citrate in combating Alopecia Universalis, as well as potentially other forms of hair loss, is safe. Particularly given the alarming side effects associated with the drug in connection with its treatment of rheumatoid arthritis in adults and various other conditions it has been tested for as a potential remedy, including Crohns disease, dry eyes, plaque psoriasis, renal transplant rejection,ulcerative colitis, and ankylosing spondylitis.

Many clinical trials of Xeljanz have been, and continue to be carried out in relation to the drugs suitability and safety as a treatment for rheumatoid arthritis and psoriasis. Yales Dr. King has already submitted a proposal for a clinical trial involving a cream form of tofacitinib as a treatment for alopecia areata.

Currently scheduled until November 2019, on-going clinical trials for the drug started in February 2007. In April 2011, four patients died after beginning clinical trials with tofacitinib citrate Pfizer said that only one of the four deaths was related to tofacitinib.

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How Malabsorption Can Lead To Hair Loss

Nutritional deficiencies can be a consequence of poor diet choices, or they might be a consequence of malabsorption. In certain pathological situations, even if youre eating healthy food, your body might not be able to break down and absorb the nutrients from the digestive tract.

Malabsorption can be a consequence of certain food type intolerance, local inflammation, bacterial overgrowth, autoimmune diseases of the digestive tract, or parasites. There also appears to be a strong correlation between hair loss and patients who undergo sleeve gastrectomy procedures. This type of intervention may cause malabsorption of micronutrients like zinc and iron, both of which are necessary for hair growth.

In periods of nutrient deficiencies, your body uses all its resources to keep your organs functioning properly. A process like growing hair is not a priority, so your hair might take longer to grow or it can start to thin out.

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The Normal Cycle Of Hair Growth

Scalp hair grows in cycles , with each individual follicle undergoing 10 to 30 cycles per lifetime. Active hair growth occurs during anagen, a phase which lasts 2 to 8 years. During anagen, hair follicle cells divide every 1 to 3 days, resulting in hair growth of approximately 1 cm/mo. Anagen is followed by catagen, the involuting or regression phase, which lasts 2 to 3 weeks and signals the end of active hair growth. Telogen is the resting or quiescent phase, which lasts 2 to 3 months and is followed by exogen, an active phase, where the old hair fiber is shed. Excessive hair loss is because of disruption of 1 of the phases of the cycle.

The normal cycle of hair growth. Active hair growth occurs during anagen, which lasts 2 to 8 years. Anagen is followed by catagen, the involuting or regression phase, which lasts 2 to 3 weeks. Telogen is the resting or quiescent phase, which lasts 2 to 3 months and is followed by exogen, an active phase, where the old hair fiber is shed. Excessive hair loss is because of disruption of 1 of the phases of the cycle.

Each hair follicle cycles independently such that at any one time approximately 85% of hair follicles will be in anagen, 1% to 2% in catagen with the remaining 10% to 15% being in telogen. Most people have between 100,000 and 150,000 scalp hairs, and shedding of 25 to 100 telogen hairs per day is normal however, anagen hair loss is never normal.

Does Xeljanz Cause Hair Growth Or Hair Loss

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It depends. Some studies have shown that people with alopecia may benefit from taking Xeljanz. Alopecia is an autoimmune disease that causes hair loss. At this time, Xeljanz isnt used to treat alopecia.

As for hair loss, you shouldnt experience this as a side effect of Xeljanz. Hair loss wasnt reported in people who took Xeljanz in studies.

If youre concerned about hair loss, talk with your doctor. They may be able to recommend medications to decrease hair loss.

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Will My Hair Grow Back If I Have Telogen Effluvium

While losing hair is absolutely an unwanted additional stressor on top of already being sick, its important to receive reassurance that, in most cases, your hair will grow back in time. According to Dr. Hughes:

Because acute telogen effluvium is a reactive process, which resolves spontaneously, treatment usually is limited to reassurance. 29http://emedicine.medscape.com/article/1071566-treatment

In other words, as long as the underlying cause is treated , the telogen effluvium will resolve itself.

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The Role Of Antioxidants In Inflammatory Bowel Disease

Inflammatory bowel disease such as Crohns disease and ulcerative colitis can be debilitating and can significantly impact an individuals quality of life. Along with the inconvenience of bowel irregularities, a main concern of IBD is the increased risk for colon cancer resulting from chronic inflammation of the intestines. In addition to an antiinflammatory diet, zinc, omega-3 essential fatty acids, vitamin E, probiotics, folic acid, and vitamin B12, evidence is growing for the use of antioxidants in the treatment of IBD.

Research has shown that individuals with IBD have lower circulating levels of total antioxidants in their blood and those with active disease have even lower amounts. The oxidative stress of the inflammation and the depletion of antioxidants are thought to contribute to damage to the intestinal walls.

Recently, research has also discovered prostaglandin D2, a chemical in people with IBD, which may assist with remission. What the studies indicated is that elevated levels of prostaglandin D2 were only found in patients in long-term remission. The production of prostaglandin D2 depends on the bodys most important antioxidant, glutathione. Glutathione is found to be deficient in IBD patients and increasing glutathione levels in active IBD should be considered for treatment.

Consult your local naturopathic doctor to find out more about treatment options for IBD.

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Other Methods To Treat Hair Loss

  • Probiotics are made of live yeast or bacteria. You can take probiotic supplements as a way to add good bacteria to your body. Your doctor might recommend probiotic supplements after antibiotic treatments. Studies have shown that there might be a connection between the administration of probiotics and hair growth. One clinical study has shown the improvement of hair counts, hair thickness, and hair growth in patients with androgenic alopecia.
  • Limiting hair product use can be beneficial to your hair health. Most products like shampoos contain a lot of chemicals that can dry out your scalp and hair if used too often.
  • Using brushes and combs on your wet hair can damage hair fibers. When youre drying your hair with a towel, try to be gentle and use patting motions instead of a vigorous scrub.
  • Avoid pulling out your hair with rough combing or tight hairstyles such as braids, buns, or ponytails. Using very tight hair ties can damage the hair fiber and hair follicles.
  • Try to limit the use of curling irons, straightening irons, hot rollers, or hot oil treatments. High temperatures can be very damaging for the hair fiber, and it may cause irreparable damage to your hair.

Related Diseases And Disorders

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One potential cause of hair loss in IBD is another autoimmune disease, alopecia areata. Alopecia areata attacks the bodys hair follicles, causing the hair to fall out in clumps. Recent studies have shown a correlation between alopecia and IBD and related gastric conditions. Scientists have determined potential among autoimmune conditions. In fact, some researchers estimate that one-quarter of those with one autoimmune condition have one or more additional autoimmune conditions.

The stress of IBD flare-ups can also lead to a related condition called telogen effluvium, in which changes within the body or major stressors cause the body to push more hair than normal into the telogen phase of hair growth. In people with telogen effluvium, approximately 30 percent of hair stops growing, enters the resting phase, and falls out.

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Can I Get My Hair Colored After Hair Loss From Crohn’s

I checked with a friend who has Crohns and is a hairstylist. She said this is a normal shed and it should be okay to get my color done.

When I got there, I told my stylist what happened. Shes used to my shedding more than her other clients and always checks my scalp for issues before applying color.

Once the color processed, she set out to wash the dye out and condition. I could feel my stylist pulling more shed hair off, each time she rinsed.

When it was time to go back to her chair to brush the knots out, I noticed something was off. I felt a giant mass of knotting at the ends. But this didnt feel like typical knots.

Clutched between my fingers, I focused my gaze on the knotted mess resting along the ends of my hair. It wasnt a knot per se.

This was a lot of hair that was no longer attached to my scalp. It became caught up in the ends during the wash and condition cycle.

What the H***! Flew out of my mouth.

As I loosened and removed the knotted up mess from the ends, my blood ran cold and I wanted to vomit.

You see tropes in movies and on TV where someone burns their hair off with something and is screaming dramatically while clutching what was once attached to their skull. That was me minus the screaming because I didnt want to terrify my stylist.

Seeing my panic, my hairstylist sat me in the chair and looked over my scalp and hair again. All was good, and most likely this was just part of the hair shed. My friend the stylist later said the same.

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