The Healing Effect Of Aloe Vera Gel On Acetic Acid
Seyed Jalil Masoumi, Davood Mehrabani, Negar Hassanshahi, Seyedeh Sara Hashemi, Morteza Zare
Abstract
BACKGROUND:
The use of herbal and synthetic compounds can be effective in improving the areas and repair of tissues that have been affected during the processes like what happens in ulcerative colitis as a common inflammatory disorder. According to the beneficial effects of aloe vera, in this study, we aimed to assess the therapeutic effects of oral aloe vera gel on acetic acid-induced colitis in rats by histopathological and molecular analysis of Bax, and BCL-2 genes expression in colon tissue samples.
METHODS:
RESULTS:
Histologically, aloe vera gel treatment could reduce and heal colon tissue damages in induced colitis. Also, this gel reduced apoptosis in rats colon with acetic acid-induced colitis, which showed in significantly decreased in Bax mRNA expression and significantly increased BCL-2 mRNA expression compared with the colitis group with no treatment.
Aloe vera gel has a significant effect on the treatment of UC in rat because of the beneficial effect that was found from aloe vera such as decreasing the severity of colitis as evidenced by histopathological findings, and with respect to apoptosis and gene expression that were related to wound healing process, and suppression of the elevation of Bax mRNA with the upregulation of Bcl-2, which can be considered effective in the treatment of UC.
Keywords
Does Aloe Vera Juice Need To Be Organic
Ingredients. When purchasing an aloe vera juice, always look carefully at the ingredient list to see what is in the product. Look for organic, pure juice that is as close to 100% juice as possible. Avoid any artificial ingredients, and when possible, choose a product with natural preservatives like lemon juice.
How To Use Fresh Aloe Gel
You can apply fresh aloe gel directly to your skin or follow a recipe to make a homemade beauty product. It can also be added to food, smoothies, and drinks.
To make aloe juice, use 1 cup of liquid for every 2 tablespoons of aloe gel. Include any other ingredients, like fruit, and use a blender or food processor to mix up your drink.
If youre planning to consume the fresh slices of aloe gel, it will keep in the refrigerator for a few days, but its best to consume it as quickly as possible. You can always store aloe vera gel in the freezer if youre not ready to use it right away.
There are plenty of ways you can use aloe vera, both topically and internally.
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Measurement Of Clinical Disease Activity
Disease activity scores were calculated using the SCCAI. This was modified to allow inclusion of patients with active proctitis, but without increased stool frequency. The modification involved altering the scores for stool frequency so that patients recording zero or one bowel movement in a day scored zero, those with 23 stools scored 1 point, those with 46 scored 2, those with 79 scored 3 and those with > 9 scored 4. To confirm the validity of this minor modification, we showed that, in patients at baseline, the SCCAI was significantly negatively correlated with the IBDQ it also correlated positively with the Baron sigmoidoscopic score .
Role Of Hyaluronan In Inflammatory Bowel Disease: Promoting Defense Of The Intestinal Epithelium
Petrey and de la Motte discussed the functional significance of HA in the cells and tissues involved in inflammatory bowel disease pathobiology, and reviewed that regulation of HA-degrading enzymes is disrupted in IBD and HA regulates megakaryocyte and platelet maturation. The authors reported that HA is a novel regulator of the immune response in IBD.
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How To Drink Aloe Vera Water
Blend the clear gel with water and flavorings. Place the gel from one large aloe leaf in the blender with two cups of water and blend on medium speed until combined. If you dislike the texture of pure aloe gel, you can strain the aloe-water mixture through cheesecloth to catch anything the blender missed.
Therapeutic Effect Of Aloe Vera Gel On Ulcerative Colitis Induced By Acetic Acid In Rats
Ulcerative colitis is a chronic intestinal inflammation. Bahrami et al investigated the protective and therapeutic effects of aloe vera gel on 4% acetic acid-induced UC into the rectum in rats. The results of the macroscopic and microscopic examination showed protective and therapeutic effects of 50 mg/kg dose of aloe vera gel extract on acetic acid-induced colitis in rats which reduces the inflammation, ulcers and tissue damage compared with negative control. Based on the results aloe vera gel could be used to improve the symptoms of UC as well as prevent people who are susceptible to the UC.
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What Is Aloe Vera
Aloe vera is a medicinal plant thats been used to treat various health conditions for thousands of years. Its usually safe to use also vera directly from the plant or you can buy it in gel form.
Aloe vera creams, gels, and ointments contain the clear gel found in aloe veraleaves. These products can be applied topically to treat various skin conditions. Aloe is sold in capsule or liquid form to take internally to promote health and well-being.
Read on to learn how to use aloe vera and the potential benefits and risks.
How To Drink Aloe Vera Gel Forever Living
- Aloe vera gel can be consumed alone, and a tip for doing this successfully is to think only of its benefits and not your need for something sweet.
- Or you can improve the taste to your liking by mixing the juice with a fruit juice, smoothie recipes, or anything else you choose.
- The gel should be consumed in the morning on an empty stomach. This helps to boost its absorption into the small bowel without being affected by stomach acids or enzymes.
- The dosage can be down to your discretion and that of a doctor or health expert, and this might vary from 100-150mls per day
- Shake the bottle well before each use. Take 60- 120mls daily. Children should take much less than this
- Keep the juice refrigerated after opening for the first time and out of reach of children.
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Aloe Vera Is Used For:
Aloe vera can be used topically or orally. When taken orally, aloe soothes the gastrointestinal tract. One study found aloe vera gel to be beneficial for those with ulcerative colitis. A review of studies also found aloe vera gel to be helpful when used as a mouthwash to prevent oral mucositis in people undergoing cancer treatment. When used topically, as a gel from the leaves, aloe is an effective, natural treatment for a variety of skin conditions, including burns, abrasions, cold sores, psoriasis, sunburn and frostbite. Three studies have shown that aloe vera gel has some beneficial effect as a topical treatment for mild psoriasis. While widely thought to promote the healing of wounds, studies of this therapeutic use have yielded mixed results.
Consider Therapy To Help Manage Stress And Pain
Working with a therapist on certain mind-body techniques can help you control ulcerative colitis symptoms.
Cognitive behavioral therapy and a technique called biofeedback may be useful, as these processes teach skills to cope with stress and pain. In CBT, you learn to recognize and change behaviors and emotions that affect you physically. According to an article in Therapeutic Advances in Gastroenterology, CBT can ease abdominal pain for some people. Biofeedback will teach you how to identify and control some bodily processes, such as heart rate or tension in your muscles, and it can be effective in helping manage chronic pain.
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Preparation Of Calcium Phosphate
Ahmadzadeh-Asl et al investigated calcium phosphate cements prepared by using hyaluronic acid solutions with two different molecular weights. The results revealed that the long setting time and the low compressive strength of the CPC could be improved drastically by using HA in the cement composition, in molecular weight dependent manner, suggesting that calcium phosphate nanocomposite cement obtained by HA solution can be successively used as injectable bone filler material.
In a biomimetic approach, to enhance cartilage synthesis and regeneration, Wang et al prepared amorphous inorganic polyphosphate micro-particles with Mg2+ as a counter-ion. Similar particles were obtained addition of Mg2+ ions to a solution containing HA, as a major component of the synovial fluid and soluble Na+-polyP and Ca2+ polyP. The authors proposed a strategy for treatment of joint dysfunction caused by osteoarthritis based on the application of amorphous Mg2+-polyP micro-particles that prevent calcium crystal formation in the synovial fluid using scavenging Ca2+ polyP ions and enhance chondrocyte function after binding of the Ca2+-polyP to HA at the cartridge surface. In complex polyP, HA might be protected against enzymatic degradation by hyaluronidase.
Walker et al published several preparations of HA being available for many United State, FDA Labelled indication, for cosmetics and intraarticular uses.
How To Drink Aloe Gel
Making Aloe Palatable. Most people find unflavored aloe to be unpalatably strong and bitter, making it a chore to drink the recommended 2 to 8 ounces per day. To make aloe more drinkable, you can cut its puckering taste with another liquid. Mix it with juice, whip it into a smoothie or pour a shot or two into a tall glass of sweetened iced tea.
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Get Regular Exercise To Reduce Uc Inflammation
Snider says exercise is useful in managing many of the complications associated with ulcerative colitis, including decreased bone density, a weakened immune system, emotional health problems, stress, and weight gain.
“Try to engage in a moderate-intensity exercise like swimming or biking, three or four days per week,” he says. A review published in August 2016 in Pharmacological Reports noted that moderate exercise releases protective myokines such as irisin from working skeletal muscles, which promotes healing and helps with inflammatory bowel disease inflammation.
Snider also strongly recommends yoga as a natural treatment for ulcerative colitis, as it promotes relaxation and targets the digestive system, flooding the area with oxygen and nutrition for healing. Find what type and frequency of exercise works for you and take it slow: Too much exercise can cause mild systemic inflammation.
Research indicates that stress plays a role in inflammatory bowel diseases such as ulcerative colitis. Researchers analyzed data on 2,007 adults in a Swiss IBD study and found a relationship between depression and anxiety and disease symptoms. The results were published in June 2016 in Clinical Gastroenterology and Hepatology.
Counteract stress with relaxation techniques such as meditation, deep breathing, and progressive muscle relaxation to help your body relax.
How To Take Aloe Vera Orally
Aloe Vera comes in several different forms when it comes to oral intake, the most common being juice and powder. If you decide to go with powder as it can be mixed with smoothies and food as well as water, the recommended initial dosage is ½ tsp. If need be, you can increase the dosage gradually to 1 or even ¾ tsp. Of course, make sure to consult with your doctor on the right dosage for your particular case.
If youre interested in managing the symptoms of ulcerative colitis in a more natural way, you cant go wrong with A.M.P. Floracels Aloe Vera products. They contain the Aloe Mucilaginous Polysaccharide molecule, which is the secret behind our products efficiency. Namely, the AMP molecule allows for the better absorption of the plants benefits and stronger anti-inflammatory effect.
Taking A.M.P. Floracels natural supplements regularly may lead to an immune system boost as well as a restored balance within the digestive tract. As your body absorbs the AMP nutrients, healthy gut flora can flourish once again, thus soothing and reducing the inflammation and ulcers, and further promoting the healing process. The thriving gut flora will effectively coat the digestive tract, which is how the infected and inflamed areas receive immediate relief as well as adequate protection from the damaging agents. In case you have any questions about Aloe Vera for ulcerative colitis and other health benefits of Aloe Vera, dont hesitate to contact us at A.M.P. Floracel.
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Benefits Of Aloe Vera Juice In Ulcerative Colitis
Aloe vera is a stemless, drought resistant, thick and fleshy plant which finds its use in almost all the commercial products including beverages, cosmetics, medicines etc.
This widely cultivated ornamental plant, also known as the Plant of Immortality, is almost 99% of water.
The gel contains glycoproteins which speed up the process of healing and polysaccharides which stimulate skin growth and repair.
A form of inflammatory bowel disease is Ulcerative colitis which causes inflammation and ulcers in the colon and rectum area.
The ulcer leads to the formation of wounds which bleeds and leads to the formation of pus and mucus and the inflammation results in diarrhoea.
It can be painful and can cause life-threatening complications. The symptoms of Ulcerative colitis include abdominal pain, diarrhoea, bloody stool, weight loss, malnourishment, anaemia, fever, joint pains, etc.
The main causes of ulcerative colitis can range from genetics, faulty immune system reactions diet high in sugar, cholesterol, and fat and environmental influences.
There is no permanent treatment found for ulcerative colitis yet, but various medications, lifestyle changes, and surgery can be done to prevent the worsening and reducing the intensity of the disease.
The use of aloe vera has proven to be very useful in the treatment of ulcerative colitis because it has anti-inflammatory properties and also because of its healing property which helps to reduce the ulcers.
How To Drink Aloe Vera For Digestion
Drinking aloe vera will help with all of these because it can improve nutrient absorption and aid with better digestion overall. It also promotes a healthy balance of bacteria in the gut by supporting the growth of probiotics. These are beneficial bacteria that naturally live in the gut and can use aloe vera for nutrition.
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Active Ingredients And Mechanisms Of Action
A large number of biological activities have been ascribed to Aloe vera to explain its purported health benefits, including antimicrobial, anti-inflammatory, lipid and glucose lowering, antiproliferative, immunostimulatory, and antioxidant functions. A number of potentially active ingredients in the latex and gel of Aloe vera have been identified however, much has yet to be determined about their mechanisms of action. Further studies are also required to determine the active properties of numerous other Aloe vera constituents and to explore the competitive or synergistic actions of particular combinations of ingredients.
How To Harvest The Plant
Its relatively simple to harvest an aloe plant for gel and juice. Youll need a mature plant thats at least a few years old. This ensures a higher concentration of the active ingredients.
Youll also want to wait a few weeks before cutting leaves from the same plant. You may want to have a few plants on rotation if you plan to harvest aloe often.
To harvest your aloe plant for gel and juice:
If you want smooth aloe gel, after separating the aloe from the exterior part of the leaf, you can put the aloe into a blender and then strain the substance to remove the pulp.
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How To Drink Aloe Vera Water Drink
Blend the clear gel with water and flavorings. Place the gel from one large aloe leaf in the blender with two cups of water and blend on medium speed until combined. If you dislike the texture of pure aloe gel, you can strain the aloe-water mixture through cheesecloth to catch anything the blender missed.
How Do You Make Aloe Vera Drink
- Put the aloe vera gel into a blender, and add some citrus juice, such as orange or grapefruit. The juice helps to briefly stabilize the exposed aloe vera gel, as well as enhancing the taste. Blend these ingredients for about two minutes. Pour the aloe vera juice into an airtight container.
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Power Calculations And Statistical Analysis
On the assumption of a 10% clinical remission rate with placebo and a 50% remission rate with aloe vera gel, and with the use of a 2:1 aloe vera:placebo randomization scheme, 45 patients were required to detect this difference at the 5% level of significance with 80% power. All patients who met the inclusion criteria and were effectively followed up were included in the analyses.
Fisher’s exact test was used to compare treatment and placebo groups with respect to gender. The chi-squared test was used to compare treatment and placebo groups in relation to baseline disease extent and therapy. The MannWhitney U-test was used to compare the groups at baseline in relation to age, SCCAI, IBDQ, sigmoidoscopic score, histological grade and blood results. Correlations at baseline between SCCAI, IBDQ and sigmoidoscopic score were assessed by Spearman’s rank correlation test.
Statistical calculations were made using computer software programs . Numerical results are expressed as the median and interquartile range. Because all the comparisons to be made were planned prospectively, no correction for multiple comparison was applied. All tests were two-tailed and significance was reported at the 5% level.