How Do H Pylori Cause A Peptic Ulcer And Peptic Ulcer Disease
H. pylori are spiral-shaped bacteria that can cause peptic ulcer disease by damaging the mucous coating that protects the lining of the stomach and duodenum. Once H. pylori have damaged the mucous coating, powerful stomach acid can get through to the sensitive lining. Together, the stomach acid and H. pylori irritate the lining of the stomach or duodenum and cause a peptic ulcer.
Peptic Ulcer Facts And Picture
- Peptic ulcer are sores in the lining of the esophagus, stomach or duodenum.
- The main symptom of a stomach or duodenal ulcer is upper abdominal pain, which can be dull, sharp, or burning .
- Other associated symptoms may include:
- Acid reflux or heartburn
- Feeling satiated when eating
How Does H Pylori Cause Ulcers
Although many people naturally carry H. pylori, it is not clear why the bacteria only cause ulcers in some people. H. pylori spread through food and water. They live in the mucus that coats the lining of the stomach and duodenum, and they produce urease, an enzyme that neutralizes stomach acid by making it less acidic.
To compensate for this, the stomach produces more acid, and this irritates the stomach lining. The bacteria also weaken the defense system of the stomach and causes inflammation. Patients with peptic ulcers caused by H. pylori need treatment to get rid of the bacterium from the stomach, and to prevent them coming back.
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How To Prevent Ulcers
Be careful when taking pain relievers.
Patients suffering from arthritis and other medical conditions which cause chronic pain, often take non-steroidal anti-inflammatory drugs or NSAIDs for months and weeks to alleviate the swelling and pain. These pain relievers can have a negative effect on the mucus which protects your stomach from acid, increasing your chances of developing peptic ulcers.
These pain relievers include:
- Naproxen sodium
To lower the chances of developing peptic ulcers while taking NSAIDs, it is advisable to take the lowest possible dose to ease your symptoms. Take your medication with food and stop taking it as soon as you dont need it. It is also advisable to avoid drinking alcohol while taking these medications.
What Ulcer Treatments Are Available
If your ulcer is bleeding, your doctor may treat it during an endoscopy procedure by injecting medications into it. Your doctor could also use a clamp or cauterization to seal it off and stop the bleeding.
For most people, doctors treat ulcers with medications, including:
- Proton pump inhibitors : These drugs reduce acid, which allows the ulcer to heal. PPIs include Prilosec®, Prevacid®, Aciphex®, Protonix® and Nexium®.
- Histamine receptor blockers : These drugs also reduce acid production and include Tagamet®, Pepcid®, Zantac® and Axid®.
- Antibiotics: These medications kill bacteria. Doctors use them to treat H. pylori.
- Protective medications: Like a liquid bandage, these medications cover the ulcer in a protective layer to prevent further damage from digestive acids and enzymes. Doctors commonly recommend Carafate® or Pepto-Bismol®.
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Will Surgery Cure A Peptic Ulcer
Medical therapy works in most people with peptic ulcers. Sometimes, medical therapy does not work, or a person cant take the therapy for some reason. Surgery is an alternative to medical therapy for these people.
Surgical operations often used in peptic ulcers include the following:
- Vagotomy: Cutting the vagus nerve, which transmits messages from the brain to the stomach, can reduce acid secretion. However, this can also interfere with other functions of the stomach. A newer operation cuts only the part of the nerve that affects acid secretion.
- Antrectomy: This is often done in conjunction with a vagotomy. It involves removing the lower part of the stomach . This part of the stomach produces a hormone that increases production of stomach acid. Adjacent parts of the stomach may also be removed.
- Pyloroplasty: This procedure also is sometimes done with vagotomy. It enlarges the opening between the stomach and duodenum to encourage passage of partially digested food. Once the food has passed, acid production normally stops.
- Tying off an artery: If bleeding is a problem, cutting off the blood supply to the ulcer can stop the bleeding.
What Is A Stomach Ulcer
A stomach ulcer, also called a gastric ulcer, is an open sore that develops in your stomach lining. You can also get one in your duodenum, the first part of the small intestine that your stomach feeds into. Duodenal ulcers and stomach ulcers are both types of peptic ulcers. Theyre named for pepsin, one of the digestive juices that are found in the stomach and that sometimes leak into the duodenum. These juices are a contributing factor in peptic ulcer disease.
Peptic ulcers occur when the protective mucous lining in your stomach and duodenum has been eroded, allowing gastric acids and digestive enzymes to eat away at your stomach and duodenal walls. This eventually results in open sores that are continually irritated by the acid. If left untreated, they can begin to cause serious complications, such as internal bleeding. Over time, they can even wear a hole all the way through. This is a medical emergency.
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Could I Have An Ulcer And Not Know It
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Around 25 million people will have a stomach ulcer in their lifetime, according to the Centers for Disease Control and Prevention. Despite their prevalence, the symptoms of an ulcer can frequently be mistaken for other conditions, like heartburnand some people may not show any signs at all. Its also unlikely that stress or your diet is the culprit. If youre concerned that your stomach pain could be something more serious, read on to find out the causes, proper treatment and prevention methods for peptic ulcers.
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Other Causes Of Peptic Ulcers
- Genetics: A significant number of individuals with peptic ulcers have close relatives with the same problem, suggesting that genetic factors may be involved.
- Smoking: People who regularly smoke tobacco are more likely to develop peptic ulcers when compared with non-smokers.
- Alcohol consumption: Regular heavy drinkers of alcohol have a higher risk of developing peptic ulcers.
- Corticosteroid use: People on large or chronic doses of corticosteroids are also at greater risk.
- Mental stress: This stress has not been linked to the development of new peptic ulcers, but symptoms appear to be more severe in people with ulcers who are experiencing ongoing mental stress.
A patientâs description of symptoms will normally cause a doctor to suspect a peptic ulcer.
Tests that can confirm a diagnosis include:
- a blood test to check for H. pylori, though a positive test does not always mean there is an active infection
- a breath test, using a radioactive carbon atom to detect H. pylori
- a stool antigen test to detect H. pylori in the feces
- an upper gastrointestinal X-ray to identify ulcers
An endoscopy may also be used. This involves a long, narrow tube with a camera attached to the end is threaded down the patientâs throat and into the stomach and duodenum. This is the best diagnostic test.
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What Are The Complications Of Ulcers
- Bleeding This can range from a trickle to a life-threatening bleed
- Perforation This is the term used to describe the ulcer having gone all the way through the wall of the stomach. It may cause severe pain and makes a patient feel very unwell.
- Stomach blockage This is a rare occurrence. An ulcer at the end of the stomach can cause the part of the stomach that goes into the duodenum to narrow and cause an obstruction. This can cause frequent severe vomiting.
- Fistula This occurs whena perforated ulcer can establish a connection with an adjacent abdominal organ or structure. Exchange of material and fluids may happen between the adjacent structures resulting in vomiting these materials or hemorrhages.
How Soon After Treatment Will I Feel Better
If you take all medicines as prescribed and avoid irritating the ulcer with NSAIDs, alcohol or smoking, your ulcer should heal well within a few weeks. Surgical cases may take a few weeks more. Your healthcare provider will follow up with you at the end of your course of medication to make sure the ulcer has healed and any infection has cleared. They will probably take follow-up tests, including an upper endoscopy to look at the site of the ulcer and tests for H. pylori, if you had it, to make sure the infection is gone.
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Burning Pain In Your Abdomen
This may seem like a no-brainer but the most common sign that people experience when they have a stomach ulcer is a persistent burning pain in their abdomen. This sensation occurs when juices in the stomach used for digestion come into contact with the open sore. For the most part, the pain is felt from the breastbone to navel and is often worse at night than during the day. On the other hand, if you are someone who frequently skips meals, you may find that you experience this pain much throughout the daytime.
Black Or Dark Colored Stool
If you think you may have an ulcer, a good way to tell is to look at your stool. If you notice that when you use the restroom your stool is extremely dark in color, or even black, chances are you are right about what is ailing you. If this is the case, you should absolutely go to the hospital immediately.
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Symptoms Of Stomach Ulcers
A number of symptoms are associated with stomach ulcers. The severity of the symptoms depends on the severity of the ulcer.
The most common symptom is a burning sensation or pain in the middle of your abdomen between your chest and belly button. Typically, the pain will be more intense when your stomach is empty, and it can last for a few minutes to several hours.
Other common signs and symptoms of ulcers include:
- dull pain in the stomach
- weight loss
- heartburn, which is a burning sensation in the chest)
- pain that may improve when you eat, drink, or take antacids
- anemia, whose symptoms can include tiredness, shortness of breath, or paler skin
- dark, tarry stools
- vomit thats bloody or looks like coffee grounds
Talk to your doctor if you have any symptoms of a stomach ulcer. Even though discomfort may be mild, ulcers can worsen if they arent treated. Bleeding ulcers can become life-threatening.
What Are Peptic Ulcers And How Are They Caused
Duodenal ulcers are common in the middle-aged and in men, whereas stomach ulcers are common in the elderly and in women.1
Peptic ulcers are open sores that develop in the lining of the esophagus, stomach, or duodenum when the protective mucus overlaying this lining is eroded.
The acid-resistant gut mucosa can be compromised because of:
- An H. Pylori bacterial infection2: This infection disrupts the integrity of the muscosal lining.
- Long-term use of NSAIDs3: NSAIDS include common OTC drugs like aspirin, ibuprofen, and naproxen.
- Zollinger-Ellison syndrome4: In this condition,abnormal gastrin secretion by tumors in the duodenum or pancreas cause stomach acids to be produced in excess of the normal. High concentrations of acid become too overbearing for the mucosal layer to counteract.
Whatever the reason for erosion of mucus, it leaves the stomach and duodenal lining exposed, vulnerable, and at the mercy of strong stomach acids.
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Youve Had Unexplained Vomiting
From time to time, the nausea brought on by ulcers may become so intense that it could actually cause you to vomit. Frequent vomiting is never a fun experience, but whatever you do, stay away from medications like ibuprofen and aspirin when treating the condition and other ulcer symptoms. According to Dr. Sengupta, these over-the-counter pain medications actually put you at a higher risk of developing ulcers, and can make your current ulcers worse.
What Are The Symptoms Of A Peptic Ulcer
Youâll most likely feel a burning pain or discomfort between your belly button and breastbone. You might especially notice it on an empty stomach — such as between meals or at night. The pain may stop for a little while if you eat or take an antacid, but then return. The pain can last for a few minutes or a few hours, and may come and go for many days or weeks.
Other symptoms may include:
Small ulcers may not cause any symptoms. But if you notice any of these signs, talk to your doctor.
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What Are The Symptoms Of A Peptic Ulcer Does It Cause Pain
Ulcers do not always cause symptoms. Sometimes, a serious complication such as bleeding or a sudden, bad upper abdominal pain is the first sign of an ulcer.
The most common symptom of peptic ulcers is abdominal pain.
- The pain is usually in the upper middle part of the abdomen, above the belly button and below the breastbone.
- The ulcer pain can feel like burning, or gnawing, and it may go through to the back.
- Pain often comes several hours after a meal when the stomach is empty.
- The pain is often worse at night and early morning.
- It can last anywhere from a few minutes to several hours.
- The ulcer pain may be relieved by food, antacids, or vomiting.
Other symptoms of peptic ulcers include the following:
- Loss of appetite
- Loss of weight
Severe ulcers may cause bleeding in the stomach or duodenum. Bleeding is sometimes the only symptom of an ulcer. This bleeding can be fast or slow. Fast bleeding reveals itself in one of the following ways:
- Vomiting of blood or dark material that looks something like coffee grounds: This is an emergency and warrants an immediate visit to an emergency department.
- Blood in the stool or black, tarry, sticky-looking stools
Slow bleeding is often more difficult to detect, because it has no dramatic symptoms.
- The usual result is low blood cell count .
- The symptoms of anemia are tiredness , lack of energy , weakness, rapid heartbeat , and pale skin .
Signs You May Have A Stomach Ulcer
We have absolutely warned our patients about the dangers of untreated ulcers in the past. However, we consider this to be an extremely important matter and therefore, we will continue to try to educate the people of Los Angeles, as well as those elsewhere on the most common symptoms of stomach ulcers. If you know the signs, you can see your doctor sooner rather than later when things have gotten especially bad. Continue reading below to get familiar with what these symptoms are.
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How Are Ulcers Diagnosed
Your healthcare provider may be able to make the diagnosis just by talking with you about your symptoms. If you develop an ulcer and youre not taking NSAIDs, the cause is likely an H. pylori infection. To confirm the diagnosis, youll need one of these tests:
If you have severe symptoms, your provider may recommend an upper endoscopy to determine if you have an ulcer. In this procedure, the doctor inserts an endoscope through your throat and into your stomach to look for abnormalities.
H. Pylori tests
Tests for H. pylori are now widely used and your provider will tailor treatment to reduce your symptoms and kill the bacteria. A breath test is the easiest way to discover H. pylori. Your provider can also look for it with a blood or stool test, or by taking a sample during an upper endoscopy.
Less frequently, imaging tests such as X-rays and CT scans are used to detect ulcers. You have to drink a specific liquid that coats the digestive tract and makes ulcers more visible to the imaging machines.
Signs That Your Horse Might Have An Ulcer
Ulcers in horses can be challenging to identify as they sometimes present with quite generic symptoms. Only veterinary diagnosis will confirm whether your horse has ulcers or not but what are the telltale signs that you should keep an eye out for? Read our handy guide and become better informed.
Ulcers can present with a range of symptoms that can easily be attributed to other conditions. If you suspect something is wrong then your vet should evaluate your horse as it could be ulcers or a different issue. Ulcers rarely heal on their own without veterinary intervention. If your horse does have ulcers, your vet will need to determine which type they are as there are two different classifications:
- ESGUS Ulcers in the upper region of the horses stomach which is called the Squamous, really the lower end of the oesophagus lining and the most common of the two types of ulcer
- EGGUS Ulcers in the lower glandular region of the horses stomach
These are some of the symptoms a horse with ulcers can exhibit:
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