Monday, July 15, 2024

Signs Of Remission In Ulcerative Colitis

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How To Know If You Are In Ulcerative Colitis Remission

Ulcerative colitis – causes, symptoms, diagnosis, treatment, pathology

Achieving remission for UC can be a challenging process. It can also be challenging to determine if you are in remission since you can have symptoms without inflammation present and you can also have relatively no symptoms and still have inflammation! Whichever the case, here are some tips on how to know if your treatments are working.

What Causes Ulcerative Colitis

Researchers think the cause of ulcerative colitis is complex and involves many factors. They think its probably the result of an overactive immune response. The immune systems job is to protect the body from germs and other dangerous substances. But, sometimes your immune system mistakenly attacks your body, which causes inflammation and tissue damage.

Efficacy Of Indigo Naturalis In A Multicenter Randomized Controlled Trial Of Patients With Ulcerative Colitis

A summary of treatments for Ulcerative Colitis

5-Aminosalicylic acid Medications

There are sulfasalazine and Mesalazine , which was introduced as a generic to mitigate the side effects of the former medicine. These are administered orally or rectally and relieve inflammation, which leads to reducing the symptoms of diarrhea, bloody bowel discharge, and abdominal pain significantly. 5-ASA medications work for mild to moderate Ulcerative Colitis and effective for preventing relapse as well.


One of the major medicines is Prednisolone . It is administered orally, rectally or intravenously. This medication is prescribed for patients with moderate to severe conditions and reduce inflammation significantly, but it is yet to be confirmed to prevent relapse.
Cytapheresis This is a therapy for ulcerative colitis to remove excess and abnormal white blood cells and there are LCAP and GCAP . Although this is not a pharmacotherapy, it is usually employed for patients who did not see improvements with Corticosteroid during their active period.
Immunomodulators This type of medication includes Azathioprine , 6-Mercaptopurine and recently there are Cyclosporine and Tacrolimus . These medications work for those who did not see improvements with Corticosteroid and who cannot stop Corticosteroid.

In conclusion, while there still needs to adequate basis for each treatment to be effective, we can say that the efficacy of indigo naturalis for this disease is significant.

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Enhancing Healthcare Team Outcomes

Ulcerative colitis is a systemic disorder with no cure. The disorder has numerous extraintestinal involvement in addition to the colon. Thus, it is best managed by an interprofessional team. All patients with the disorder need lifelong monitoring. Because of the risk of colorectal cancer, surveillance colonoscopy should occur every 1-2 years. Further, since patients are often treated with biological agents, they need to undergo screening for melanoma and nonmelanoma skin cancer.

The pharmacists should assist the team by educating the patient on the importance of medication compliance to avoid relapse. The nurse should encourage regular vaccinations, hand washing, and cancer screening. A dietary consult should be obtained to educate the patient on foods to eat and what not to eat, especially if they have a stoma. In addition, a stoma nurse should be involved in the teaching of stoma care.

An infectious disease nurse should monitor the patient in the outpatient setting to ensure that they are not immunocompromised. Social workers should be involved to ensure that the patient has ample support and finances so that the treatments are not missed. Patients with risk factors for osteoporosis need screening for bone mineral density periodically. Patients should be encouraged to undergo annual vaccination against influenza and pneumococcus. Finally, many patients with ulcerative colitis develop depression and anxiety and should be referred to a mental health counselor.


Does An Ulcerative Colitis Diet Have To Be Bland

Ulcerative colitis

So often, when you want to avoid the issues that come with colitis, Crohns, inflammatory bowel disease, and autoimmune diseases, you can stick to very few foods that seem safe and can miss out on nourishment, even when you have your bowels under control.

Fearing an attack at unpredictable times can make you not trust what you are eating, and when you are out and about, traveling and visiting , what can you eat that wont cause a flare-up?

All of this worry increases the chances of abdominal pain and needing the bathroom.

Chances are also that your body will not absorb enough nutrients because of the attacks, causing dehydration, fatigue, anemia, and headaches.

You can often be starving, but that is easier to deal with than worrying about navigating public transport, attending a meeting, being social when you need a bathroom, etc.

You may know your triggers and head to a health food store for alternatives, only to find yourself in pain not long after eating. The thing here is that the food industry relies on good marketing. We are leading such busy lives that we are not reading the small print.

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A Recommended Diet For Ulcerative Colitis

A recommended diet for ulcerative colitis on the internet by many medical authorities is the low-residue diet so that your intestines wont need to work as hard as they usually do. The low-residue diet is very restrictive and does not meet nutritional needs, so it is only for temporary measures under medical supervision.

This restrictive diet plays a role and is often recommended after bowel surgery or preparing for a colonoscopy, for instance. For an extremely limited time only because it wont reduce inflammation or treat ulcerative colitis and will likely cause more inflammation.

It is no wonder that people with ulcerative colitis often have to seek a nutritionist or dietician because there are so many ulcerative diet recommendations that will cause more inflammation and malnutrition.

If you already have weakness, headaches, anemia, and fatigue due to ulcerative colitis malnutrition, these diets will only contribute to gut dysbiosis, weaker immunity, and less-than-optimum health. This, of course, opens the body up as high risk for other illnesses and conditions.

Nutrition deficiency will present symptoms like mouth ulcers, tingling in your limbs, itchy rashes, feeling drained and weight loss, and the list goes on. If you have Diabetes, a low-residue diet will impact blood sugar and present more challenges, and so on.

Medical professionals worldwide recommend Eat Burn Sleep, as it pertains to clinical practice and has shown excellent results.

Ulcerative Colitis: Towards Remission

The initial manifestations of ulcerative colitis, although unpleasant and discomforting, are not necessarily alarming. Stomach cramps, diarrhoea and even rectal bleeding can arise from various problems of the gastrointestinal system. But if such symptoms persist or worsen, they could represent the first skirmishes in a lifelong battle with this common form of inflammatory bowel disease .

The underlying causes of ulcerative colitis are murky and complicated. Genetic factors certainly play a part: 814% of people with the condition have a family history of IBD. But myriad environmental factors, including diet and lifestyle, as well as a persons psychological wellbeing, also make a considerable contribution. The influence of external factors and their interplay with genetics can be seen in studies of migrant families. Several such investigations have shown an increased risk of ulcerative colitis in the descendants of people who have moved from parts of the world with a low incidence of ulcerative colitis to areas with a higher incidence. Furthermore, although IBD has been most prevalent historically in Western nations, its incidence is now rising in countries in Asia and Latin America too.

Nature563, S33


This article is part of Nature Outline: Ulcerative colitis, an editorially independent supplement produced with the financial support of third parties. About this content.

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Go For Regular Checkups

Your physician will schedule regular checkups to monitor your progress. You need to attend all check-ups because it can help your doctor detect any flares or side effects of the medication you are taking.

Its important to also check in with your IBD dietitian as well to monitor dietary triggers or potential deficiencies that can put you more at risk for flares.

Get Help For Uc From A Dietitian Today

Ulcerative Colitis, Crohn’s Disease & Diverticulitis – Medical-Surgical (GI) | @Level Up RN

If you are struggling with staying in remission or are frustrated by the kind of treatment youve been undergoing, thenbook a consultation with us from the comfort of your home since we work virtually.

You will get help with your UC and reach remission faster with the help of anexperienced Crohns and Colitis Dietitian.

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Pfizer Announces Fda And Ema Acceptance Of Etrasimod Regulatory Submissions For Ulcerative Colitis

– Filings based on two Phase 3 trials demonstrating significant clinical remission versus placebo and safety profile consistent with previous studies

NEW YORK, December 21, 2022—-Pfizer Inc. announced today that the U.S. Food and Drug Administration has accepted for review a New Drug Application for etrasimod for individuals living with moderately-to-severely active ulcerative colitis . The FDAs decision is expected in the second half of 2023. The European Medicines Agency has also accepted the Marketing Authorization Application for etrasimod in the same patient population with the decision anticipated in the first half of 2024.

Etrasimod is an oral, once daily, selective sphingosine-1-phosphate receptor modulator designed for optimized pharmacology and engagement of S1P receptors 1, 4, and 5. In addition to UC, it is being investigated for a range of other immuno-inflammatory diseases.

UC is a chronic and often debilitating condition1 that affects an estimated 3.8 million people in North America and Europe.2 Symptoms of UC can include chronic diarrhea with blood and mucus, abdominal pain, and urgency.3,4 UC can have a significant effect on work, family, and social activities. There is a need for additional advanced therapeutic options in UC that are oral, effective, and have a favorable risk-benefit profile.

About ELEVATE UC 52 and ELEVATE UC 12ELEVATE UC 52 and ELEVATE UC 12 are pivotal trials that are part of the ELEVATE UC Phase 3 registrational program.5


Small Intestinal Bacterial Overgrowth

Our guts are made up of trillions of bacteria. The majority of these bacteria live in our colon but sometimes some of the bacteria which should be living in your colon ends up in your small intestine1. This is known as small intestinal bacterial overgrowth – or SIBO. In a small number of cases SIBO occurs as a result of an overgrowth of the bacteria which are meant to be in your small intestine. This overgrowth can interfere with digestion of food and absorption of nutrients. This tends to happen by the bacteria damaging the cells lining the small bowel . Some people believe this damage can lead to leaky gut although not all medical professionals recognise this as a condition.

Symptoms of SIBO include bloating, abdominal distension, abdominal pain or discomfort, diarrhoea, fatty stools, fatigue, gas, belching, and weakness. In some severe cases weight loss and nutritional deficiencies may be present, particularly iron and vitamins A, B12, D, E and K. It can cause serious health issues if left untreated.

The believed cause of SIBO is complicated and may be as a result of a number of factors . These can include:

  • Low stomach acid
  • Diabetes mellitus
  • Multiple courses of antibiotics
  • Organ system dysfunction, such as liver cirrhosis, chronic pancreatitis, or renal failure
  • Moderate to high alcohol consumption
  • Oral contraceptive pills
  • Immunosuppressant medications and proton pump inhibitors

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Recognizing Symptoms Of Kidney Dysfunction From Crohns And Ulcerative Colitis

Having Crohns disease or ulcerative colitis both types of inflammatory bowel disease can put you at an increased risk of developing kidney disease. Research has shown that about 8 percent of people with either Crohns or ulcerative colitis experience some sort of kidney dysfunction, compared to less than 4 percent of the general population.

The direct correlation between IBD and kidney disorders is unknown, but experts believe kidney problems may be associated with side effects from IBD medication, inflammation, and metabolic disorders related to IBD. Heres how to recognize potential symptoms of kidney dysfunction in Crohns or ulcerative colitis.

My Journey Of Remission Of Ulcerative Colitis

Pin on Diseases

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These are the articles about efficacy of indigo naturalis.

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Cut Out Raw Veggies And Other Gut Irritants

In the midst of a ulcerative colitis flare, you want to be as gentle on your digestive system and colon as possible. Give your gut a little vacation, says Cohen. This ideally means eliminating or scaling back on: raw vegetables, raw and cooked fruits, high-fat foods , high fiber foods , spicy foods, alcohol, and caffeinated beverages. Basically, any food that takes significant digestive effort or stimulates the bowels.

Why Patients Stop Uc Treatment

People stop taking their ulcerative colitis medications for a number of reasons, says Phanijphand.

One of the leading reasons is the steep cost of the drugs. The out-of-pocket cost for prescription medicines can run over $2,000 per year, while the cost of UC care in general can run from roughly $15,000 to $25,000 per year, according to a study published in Inflammatory Bowel Diseases in January 2020.

The study also found that patients using biologics had the highest costs. Treating UC with corticosteroids had higher costs than with nonsteroidal anti-inflammatory drugs, but the latter groups costs rose more over time.

Also, when a person feels better, they may decide they no longer need UC medicine.

âSome patients think that once their symptoms are gone, they can stop taking their meds,â Phanijphand says. âThey believe theyâre cured or that they may have been misdiagnosed.â

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Many Disease Activity Indices Exist For Ulcerative Colitis But None Have Been Developed With Formal Patient Input

There is no consensus gold standard for the evaluation of disease activity in ulcerative colitis. This is illustrated in numerous recent clinical trials, in which investigators measured several different indices of disease activity, as no one index is considered sufficient. There are many indices for the measurement of ulcerative colitis disease activity, including Truelove and Witts classification of mild, moderate, and severe disease the St Marks Index, which empirically added endoscopy in 1978 simplified versions of the St Marks Index, including the Ulcerative Colitis Disease Activity Index and the Mayo Score and noninvasive versions, including the Seo Index and the Simple Clinical Colitis Activity Index .

The diversity of indices suggests that none of these has proven satisfactory, and none was developed with patient input. In addition, it has never been established that any of these indices actually measures all of the important symptoms of ulcerative colitis.

Ulcerative colitis lacks a validated measurement instrument such as the Crohns Disease Activity Index in Crohns disease . Furthermore, the indices that do exist for ulcerative colitis were not constructed in a patient-centered manner to attempt to capture the symptoms experienced by patients. Therefore, our study group aimed to investigate through focus groups that what symptoms does patients with ulcerative colitis experience during their disease process.

I Remembered What It Was To Have A Life Again

Ulcerative Colitis Diet, Treatment, Symptoms Flare Up | Nursing NCLEX Review

Mary Elizabeth Ulliman, 33, was diagnosed with ulcerative colitis in 2011 and says she was fatigued and made constant trips to the bathroom. But in 2015, Ulliman started taking two new medications that greatly improved her symptoms.

After a few months, I started noticing differences, she tells SELF. By 2016 my quality of life had done a complete 180 from where Iâd been since 2011, she says. In the thick of my ulcerative colitis journey, I genuinely forgot how much fun life could be. I was slogging through, day after day, thinking that feeling miserable was how it was going to be forever, willing myself to make it through work days so I wouldnât lose my job and insurance.

Remission, she says, allowed her to live fully again. Suddenly, life wasnât made up of sleeping, bathroom trips, forcing myself to eat, and willing myself to not fall asleep at my desk at work, she says. I had some extra energy. I startedhesitant, at firstto exercise. I could eat food without immediately regretting it afterward. I could have a glass of wine now and again. I had the wherewithal to do activities after workcoaching, going to a happy hour, taking my dog to play. I remembered what it was to have a life again.

Ulliman wants other ulcerative colitis patients to have hope. When youâre in the black hole that is trying to find somethinganything that will work to control your it can be easy to forget how much fun and joy life can bring you, she says. Mary Elizabeth Ulliman


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You Begin Doing The Things You Used To Do

You will know the treatment and medication are working when you start doing the things you enjoyed doing before. For instance, going out or taking on extra activities. As long as you are maintaining your treatment plan and avoiding triggers, there should be no problem with doing the things you enjoyed doing before.

What Role Does Diet And Nutrition Play In Ulcerative Colitis

Diet does not cause the development of ulcerative colitis nor can any special diet cure the disease. However, the foods you or your child eat may play a role in managing symptoms and lengthening the time between flareups.

Some foods may make symptoms worse and should be avoided, especially during flareups. Foods that trigger symptoms are different from person to person. To narrow down what foods affect you, keep track of what you eat each day and how you feel afterward .

Problem foods often include:

  • High sugar foods and drinks.
  • Carbonated beverages.
  • High-fiber foods.

In addition to the problem foods listed above, infants, children and teenagers can also experience issues with:

  • Dairy products.

Keep a careful eye on your childs diet and nutrition. Their appetite may decrease during a flareup and they might not eat enough to stay healthy, and grow. Also, the inflammation caused by ulcerative colitis may keep their digestive tract from absorbing enough nutrients. This can also affect your childs health. For these reasons, you may have to increase the amount of calories your child consumes.

Its best to work with your provider and nutritionist to come up with a personalized diet plan if you or your child has ulcerative colitis.

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