Stem Cell Treatment For Ulcerative Colitis

Crohns Disease And Ulcerative Colitis

Ulcerative Colitis and how it can be treated with Stem Cells

Stem Cell Therapy for Crohns Disease, Ulcerative Colitis and Inflammatory Bowel Disease in Mexico

R3 International offers stem cell therapy for Crohns Disease, Inflammatory Bowel Disease and Ulcerative Colitis that is both clinically effective and also cost effective!

These conditions are truly detrimental to an individuals quality of life and all too often do not respond well to traditional treatment options. In fact, the side effects from treatment medications may make it necessary to take MORE medications to alleviate them!

Antidiarrheals

All too often, these end up failing for patients, and eventually a risky surgical option may ensue.

Is there another option??? Absolutely, stem cell therapy for Crohns, IBD and UC is a great option at our Mexico stem cell treatment clinic. So many patients receive benefit from this extremely safe and cost effective therapy.

Quite a few recent studies have shown just how well mesenchymal stem cell therapy works for inflammatory diseases like Crohns, IBD and UC.

One was published in 2018 and looked at the effectiveness of MSCs for inflammatory diseases and showed that they orchestrate local and systemic innate and adaptive immune responses through the release of various mediators, including immunosuppressive molecules, growth factors, exosomes, chemokines, complement components and various metabolites.

Nat Rev Nephrol. 2018 Aug 14:493-507. doi: 10.1038/s41581-018-0023-5.

The Etiology And Pathogenesis Of Uc

Though the etiology of UC has not been defined clearly, the disease is believed to be multi-etiological. It is driven by immune dysregulation of mucosa toward luminal bacterial floral, an immune imbalance between regulatory and effector T cells, and the inflammatory cascade induced by leukocyte recruitment, infection, genetic alterations, and environmental factors such as diet, lifestyle, and socioeconomic development that lead to destruction of the epithelial barrier. Recent studies indicated both innate and adaptive immunity to play a part in disease pathogenesis . Various factors, such as inflammatory reaction, tight junction epithelial barrier dysfunction, and apoptosis are also associated with the disease .

Is There A Cure For Crohn’s

Unlike ulcerative colitis, a similar inflammatory bowel disease, Crohn’s disease has no surgical cure. However the symptoms of Crohn’s can be managed with new Crohn’s medication, which may include immunosuppressives, antibiotics, antidiarrheal, or corticosteroids. Stem cell therapy may also be a viable treatment option for those suffering from Crohn’s, mainly due to the treatment’s ability to target and alleviate inflammation, the underlying symptom of the condition.

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In Vivo Studies On Treatment Of Uc Using Adscs

Regarding the use of AdSCs in the treatment of UC, rats and mice were used as experimental models of DS- and TNBS-induced colitis injuries . In a TNBS-induced colitis rat model, the therapeutic potential of AdSCs was confirmed via the inhibition of inflammatory and autoimmune responses . In a TNBS-induced colitis rat model, the immunoregulatory impacts of locally submucosal endoscopic injection of AdSCs was demonstrated via the expression of Foxp3 and IL-10 mRNA ameliorating colitis injuries with fewer inflammatory infiltrates and almost complete absence of tissue edema . In a TNBS-induced colitis rat model, a combination therapy of AdSCs and sulfasalazine could attenuate the lesions via the S1P pathway . In a TNBS- and DSS-induced colitis mice model, AdSCs were found to induce immunomodulatory macrophages and to protect them from experimental colitis and sepsis .

Isolation And Culture Of Adscs

H-ADSCs and P-ADSCs were enzymatically isolated, as previously described . Briefly, AT samples were washed with phosphate-buffered saline in a 50 ml Falcon tube and digested with 50 ml of 0.2% collagenase type IV at 37°C for 30 min. The cells were centrifuged to obtain stromal vascular cells, which were then cultured at a density of 2×105 cells/mL in 5% human platelet lysate -supplemented medium. Media were replenished after 2 days, and the non-adherent cells were discarded. Thereafter, media were replaced twice weekly. Both types of cells were passaged using trypsin-EDTA when 8090% confluent and seeded at 3,000 cells/cm2.

What Is Ulcerative Colitis

Ulcerative Colitis which is an inflammatory bowel disease is a long-term, chronic disease of the digestive tract. During the course of this disease, some changes occur in the layer covering the inner surface of the digestive tract depending on the severity of the disease. The cause of these changes is the inflammatory reaction . This inflammatory reaction mostly occurs on the inner surface of the intestine and is characterized by ulceration, swelling, injury, bleeding and irritation in the layer that covers the inner surface of the intestine.

In the area of inflammatory changes, ulcers occur in the mucosa, which is the coating layer covering the inner surface of the intestine and for this reason, the disease is called ulcerative colitis, which means disease characterized by ulcers.

In the large intestine , rectum and left colon are affected the most. Other parts of the digestive tract are not affected.

There are two different types of inflammatory bowel disease: Ulcerative Colitis and Crohn’s Disease. Apart from these, there is another type of this disease which is not similar to both types, which is in between.

Inhibition Of Immune Cell Trafficking

Inhibition of immune cell trafficking has emerged as a major therapeutic principle in IBD. Immune cells circulate within the blood stream and lymphoid organs, and specific mechanisms ensure homing of leukocytes into specific organs. Integrin-47 is specifically expressed on lymphocytes activated in gut lymphatic structures. This integrin interacts with mucosal addressin cell adhesion molecule-1 , expressed on blood vessels of the intestinal tract and intestinal lymphatic structures . Therapeutic interference with gut homing offers the promise of a gut-specific mode of action with potentially low systemic immunosuppression.

Natalizumab, a monoclonal antibody targeting the integrin-4 subunit, is an effective treatment of IBD . However, since the integrin-4 subunit is also critical for 41-dependent central nervous system homing of lymphocytes, natalizumab treatment can be complicated by progressive multifocal leukoencephalopathy due to JC virus reactivation . Therefore, natalizumab is only rarely, if ever, used for IBD treatment and only in patients with JC-negative serology or with a very strict surveillance framework .

Expert Opinion

Stem Cell Therapy For Ulcerative Colitis

What is Ulcerative Colitis?

Ulcerative colitis is a chronic, idiopathic inflammation of the large intestine , which is classified as a form of inflammatory bowel disease . It is characterized by a relapsing and remitting course. Both male and female are affected equally, mostly between the ages of 30-40 years.

The incidence of this autoimmune condition and other immunological diseases has been increasing around the world. The highest annual incidence reported was 24.3 per 100k person-years in Europe and 19.2 per 100k person-years in North America.

What is the Clinical Presentation?

Patients with UC present ulcers and inflammation of the inner lining of the colon and can incur symptoms of abdominal pain, diarrhea and rectal bleeding. The exact cause of the disease remains unknown. Current studies have shown that abnormal activation of the immune system, some hereditary susceptibility and alteration of the intestinal flora may play a role in the pathogenesis of the disease.

Signs and Symptoms

The symptoms may vary, depending on the severity of inflammation and where it occurs. They may include:

Diarrhea, often with blood or pus.
Abdominal pain and cramping.
Failure to grow in children

Types of Clinical presentations

It can be often classified according to the affected location:

What are the Current Treatment Options?

Alternative treatments with Stem Cells

Mesenchymal Stem Cell Therapy at Zignagenix

Mesenchymal Stem Cells In The Treatment Of Ulcerative Colitis

Stem Cells and IBD – IBD in the News

The existing clinical management includes the use of anti-inflammatory agents such as 5-aminosalicylic acids, corticosteroids and immunomodulators like azathioprine. Unfortunately, most patients experience at least one relapse every few years.

The use of mesenchymal stem cells is one of the therapies that has been widely explored. Both animal studies and human studies suggest that MSC has more significant therapeutic potential for UC, compared with conventional therapies. In 7 human trials made using MSC no adverse effects were reported.

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Ulcerative Colitis: Stem Cells Offer Additional Treatment Option

Without enough food, no human could live for more than a few weeks. But access to healthy wont keep you in good health if your gastrointestinal system cant extract the vital nutrients, vitamins, and energy you need to survive, let alone thrive.

Indeed, any disorder that interferes with digestion can cause illness, pain, or even death. One disease that can disrupt normal digestive processes is ulcerative colitis. Although the gastrointestinal tract extends from the mouth all the way down to the stomach, intestines, and rectum, ulcerative colitis affects a specific part of the digestive tract the large intestine and rectum.

In the United States, about one million people suffer from ulcerative colitis, which can be a disease that makes life miserable. Not only does it cause severe symptoms, but these symptoms can also fluctuate in severity in an unpredictable way. Patients never know when symptoms such as sudden bouts of bloody diarrhea and abdominal pain may flare up, nor when they will ease again or even get worse. This disease may become so serious that patients need to be hospitalized for treatment or even undergo surgery.

What is ulcerative colitis? An inflammatory bowel disease

Symptoms may range from mild to severe and can fluctuate over time. These symptoms include:

Abdominal pain from inflammation in the colon and rectum
Weight loss, in part from a poor appetite
Diarrhea that may include blood
Fatigue
Fever
Malnutrition and dehydration

Increased risk of cancer

Is Ulcerative Colitis A Genetic Disease

It is known to be more common in some families. First-degree relatives are also affected by the disease in about 20% of patients. However, there is no absolute genetic transition that has been identified to date but it would be fair to say that there is predisposition. For example, the risk in children with inflammatory bowel disease in both of their parents may increase up to 36%.

Undertaken Case Reports In The Treatment Of Uc By Mscs

Undertaken case reports in the treatment of UC by various sources of MSCs are presented in Table 1. In a case report, autologous BMSC transplantation as a suspension of nearly 4.0 × 108 cells was completed for the treatment of UC at several locations through submucosal injection . The findings showed alleviation of the patients symptoms furthermore, the patients recovered from hematochezia, and there was a decrease in the patients hypersensitive C reactive protein values. Colonoscopy findings were associated with a decrease in lesions and bleeding and edema in the sigmoid colon and rectum without any recurrence in the subsequent two years . In 2009, BMSCs were successfully used in patients suffering from UC as the first IV systemic cell transplantation . Transplantation of BMSCs to the patients with UC has illustrated an improved clinical course, while the duration of remission showed an increase in chronic and continuous recurrent course of disease and the risk of relapse and the frequency of hospital admissions declined in comparison to conventional therapies . In elderly patients with UC, the transplantation of BMSCs was less effective than in patients with young and middle age . In BMSCs, aging was shown to be associated with decreased proliferative capacity and a significant decrease in differentiation properties with an increase in age .

Advantages Of The Latest Treatment For Ulcerative Colitis

Stopping the pathological reaction and positive influence on ulcerative-colitis pathogenesis .

Stable remission achieved within 21 days in mild and moderate forms, lasting for 12-15 months.

Improvement of patients life quality.

The opportunity to avoid surgical intervention and subsequent patients disability.

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In Vivo Studies Using Bmscs In The Treatment Of Uc

BMSCs have been used by several researchers in the treatment of experimental colitis using various animal models, including mice, rats, and Guinea pigs . In these animals, some researchers have used trinitrobenzene sulfonic acid to induce colitis , while several studies reported the use of dextran sulfate sodium to induce colitis models and many authors applied acetic acid to induce colitis . The first BMSCs transplantation was conducted in 2006 in a TNBS-induced colitis mice model, revealing the important role of cell therapy in the repair of injured intestinal mucosa, as well as the downregulation of immune function of T cells . Allogeneic transplantation of BMSCs in a TNBS-induced colitis rat model was demonstrated to populate the cells in the injured regions of the colon . Intra-rectal administration of 1 × 106 BMSCs in TNBS-induced colitis Guinea-pig model could prevent enteric neuropathic inflammation . When the therapeutic effects of BMSCs and IFN- were compared in the treatment of a TNBS- and DSS-induced colitis mice models, it was shown that BMSCs had immunosuppressive effects and could enhance the capacity to inhibit Th1 inflammatory responses and diminish mucosal damage . Administration of the conditioned medium derived from BMSCs in a TNBS- and DSS-induced colitis rat model led to production of pleiotropic gut trophic factors and an enhancement in the repair of intestinal epithelium .

What Are The Symptoms Of Ulcerative Colitis

Ulcerative colitis is a disease that affects only the large intestine. Different names are assigned to the site involved by the disease. Therefore, various names referring to the intestinal part involved by the disease, which means the same as inflammatory bowel disease, are used.

Large intestine involvement is shortly called colitis. In addition, involvement of the entire colon is called pancolitis involvement of only the descending colon is called left colitis, and involvement of the last part of rectum, which is the last part of large intestine, is called proctitis. Complaints of a patient vary according to the location involved by the disease.

During the course of ulcerative colitis disease, a patient may develop problems only related to the digestive tract as a result of the disease as well as problems involving organs outside the digestive tract.

Ulcerative colitis disease is also classified according to the region affected by the disease. If it is only related to digestive – intestinal tract, it is called local if it is related to other organs in the body, other than the intestinal tract, or the whole body, it is called systemic involvement.

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Real Cure With Regenerative Medicine

Ulcerative colitis is a severe autoimmune disease, which is traditionally treated symptomatically with anti-inflammatory medications. The disease often ends up with surgical intervention, followed by patients disability.

Newest researches in the field suggest developed schemes of suspensions, which contain fetal stem cells and help to treat ulcerative colitis. This is the latest treatment for ulcerative colitis. Stem cell treatment represents the new branch of highly effective regenerative medicine.

This methodology is also successfully applied to the most severe cases, as well as in treatment of acute and chronic forms of the bowel disease.

What Is Unique About Receiving Stem Cell Therapy Through Trustem Cell Therapy For Ibd

Stem Cells for Ulcerative Colitis or Ayurvedic Treatment

Our focus is safety, efficacy, and patient-centric care when providing access to superior stem cell therapy.
We utilize only board certified surgeons, physicians and accredited clinicians to provide care for patients.
Laboratory protocols are developed and refined by our PhD Neuroscientist.
A clinical team with expertise in practicing cellular based medicine.
Accredited Surgical Centers for enhanced procedural and patient safety
Targeted administration methods that direct stem cells toward specific
Skilled Patient Advocates who are trained to provide truthful, realistic expectations resulting from stem cell therapy. We do not make outlandish promises of cures or inaccurate claims related to improvement rates.

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Treatments With Mesenchymal Stem Cells For Ulcerative Colitis

Patients who have suffered extensive damage to their colon are usually recommended surgical removal. However, a much safer and simpler alternative can be granted by the use of autologous mesenchymal stem cells derived from a patients bone marrow or fat tissue. If these are not available, it is also possible to use MSCs derived from placenta and cord tissue of unrelated donors.

The possible use of MSC-derived nanoparticles, exosomes, or extracellular vesicles instead of the direct use of MSCs is also currently being investigated. While it remains possible in theory, this is yet to be tested.

Mesenchymal stem cells may also be used to regenerate existing damage caused by the inflammatory reaction.

Undertaken Clinical Trials In The Treatment Of Uc By Mscs

Undertaken clinical trials in the treatment of UC by various sources of MSCs are illustrated in Table 2. In a clinical trial phase II, a single intravenous × 108 dose of allogeneic BMSCs was used in the treatment of 44 patients with UC. After 24 months of follow-up, 72.7% of patients achieved the clinical and morphological indices of inflammatory activity . The potential advantage of freshly isolated autologous AdSCs in two UC patients was described before . Among 25 UC patients treated with human peripheral blood mononuclear cells , it was shown that concomitant use of stem cells and IL-25 enhanced intestinal epithelial cell regeneration and treatment of the disease .

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